Faculty details

Prof.Ajay Bhandari

Designation: Assistant Professor

Department: Mechanical Engineering

Email: ajayb[at]iitism[dot]ac[dot]in

Contact Number:

Office Number: +91-326-223-5347

Personal Page: Click Here

About Me: I completed my Ph.D. and Master's from the Department of Mechanical Engineering, Indian Institute of Technology (IIT) Kanpur. My primary research interests include biofluid mechanics, image-based numerical modeling, the development of patient-specific models, and applying Computational fluid dynamics (CFD) to solve bio-oriented problems such as cancer and ocular drug delivery. Currently, I am working as an Assistant Professor in the Department of Mechanical Engineering at IIT (ISM) Dhanbad, where I have developed the Biofluids Research Lab. For more details, please visit my lab webpage https://prof-ajay-bhandari-profile.netlify.app/

Research Interest: Bio-fluid Mechanics And Heat Transfer, Image Based Numerical Modeling, Patient-specific Computational Models, Computational Oncology And Drug Delivery, CFD, Personalized Medicine.

Teaching

1.    Research Methodology and Statistics (PG) (Monsoon Semester 2020-21, Winter Semester 20-21, 21-22)
2.    Conduction and Radiation (UG and PG) (Winter Semester 21-22, 22-23, 23-24, 24-25), Course feedback (9.31/10 for 32 students)
3.    Fluid Mechanics (UG) (Monsoon Semester 23-24, 24-25), Course feedback (8.4/10 for 118 students)
4.    Fluid Mechanics Lab (Monsoon Semester 22-23, 23-24, 24-25)
5.    CFD Lab (Winter Semester 21-22, Winter Semester 22-23, 23-24)
6.    Biofluid Mechanics (Newly developed course for PG students)
 

Academics

Education

  • PhD (2020) Mechanical Engineering, Indian Institute of Technology, Kanpur, India

  • M.Tech (2018) (Joint M.Tech-PhD) Mechanical Engineering, Indian Institute of Technology, Kanpur, India

  • BE (2013) Mechanical Engineering,University Institute of Engineering and Technology (UIET), Panjab University (PU), Chandigarh

Experiences

  • July 2023- Present Assistant Professor (Grade I), Indian Institute of Technology (Indian School of Mines), Dhanbad

  • June 2023- July 2023 Visiting Researcher, King's College University of Aberdeen, Aberdeen, UK, Sponsor: The Royal Society

  • July 2020- July 2023 Assistant Professor (Grade II), Indian Institute of Technology (Indian School of Mines), Dhanbad

  • Jan 2020- June 2020 Senior Research Associate, Department of Mechanical and Industrial Engineering, Indian Institute of Technology (IIT), Roorkee, Sponsors: TBRL/DRDO

Position

Awards and Honors

1.    Got “Gullapalli Young Investigator Award” at Sign 2024 Conference, Hyderabad for outstanding research work in the field of Computational Oncology and awarded 1000 USD cash prize.
2.    Our idea, “Scrap to Advanced Materials by Guiding the Communities,” has been selected in the top 75 best ideas out of 2538 ideas form 67 countries for the LiFE Global Call for Ideas and Papers by Niti Aayog, Government of India. 
3.    Got the “Royal Society Yusuf Hamied International Exchange Award” funded by The Yusuf and Farida Hamied Foundation. 
4.    ASME JBME journal article got selected by Research Matters (Entrepreneurship Cell) at Indian Institute of Science (IISc) Bangalore as cutting-edge research and a research story was published on it, which appeared as a media coverage. 
5.    POF journal article got selected as Scilight article. 
6.    The ASCHT 2017 conference paper was selected to publish in a special issue of the International Journal of Advances in Engineering Science and Applied Mathematics. Only 8 out of 200 conference papers were selected for the journal.
7.    Lalit Kishore Chaudhary Memorial Award for best research paper of the Mechanical Department of IIT Kanpur.
8.    Full scholarship to present international conference in Sendai, Japan. Funding agency: IIT Kanpur, Funding amount INR 1.5 Lac.
9.    Qualified GATE in 2014 in Mechanical Engineering and got MHRD scholarship during Ph.D. 2014-19).
10.    Secured third position and first division with honors in Mechanical Engineering Batch in BE in 2013.
11.    Secured first position in 10+2 and was awarded scholarship, certificate of merit and state level award by Chief minister of Punjab.
 

Publications

List Of Research Publications (only in Peer-reviewed Journals)

1.    Anahita Piranfar, Farshad Moradi Kashkooli, Wenbo Zhan, Ajay Bhandari, and M. Soltani, A Comparative Analysis of Alpha and Beta Therapy in Prostate Cancer Using a 3D Image-Based Spatiotemporal Model, Annals of Biomedical Engineering, November 2024 Access Link IF: 4 
2.    Kartika Chandra Tripathy, and Ajay Bhandari, Effect of various septal deviations and corrections on nasal aero and particle dynamics: An insilico and invitro investigation, Physics of Fluids Vol. 36(1), pp. 091919, September 2024 Access Link IF: 4.6
3.    Ajay Bhandari, Boram Gu, Farshad Moradi Kashkooli, Wenbo Zhan, Image-based Predictive Modelling Frameworks for Personalised Drug Delivery in Cancer Therapy, Journal of Controlled Release, Vol 370, pp. 721-746, June 2024, Access Link IF: 11.467.
4.    Ajay Bhandari, Anup Singh, and Wenbo Zhan, Decoding the effect of different tumor heterogeneities on thermosensitive liposome drug delivery during radiofrequency ablation: A novel heat and mass transfer perspective, International Communications in Heat and Mass Transfer, Vol. 153, April, 2024, Access Link IF:7
5.    Anahita Piranfar, Farshad Moradi Kashkooli, Wenbo Zhan, Ajay Bhandari, Arman Rahmim, and M. Soltani, Radiopharmaceutical Transport in Solid Tumors via a 3-Dimensional Image-Based Spatiotemporal Model, NPJ Systems Biology and Applications (Nature), Vol. 10, April, 2024, Access Link IF: 4.3
6.    Ashish Siddharth, Ajay Bhandari, Sarthak S. Singh, and Arun Dayal Udai, Effect of Twisting of Intravitreal Injections on Ocular Bio-mechanics: A Novel Insight to Ocular Surgery, Biomechanics and Modeling in Mechanobiology Vol. 23(1), February 2024, Access Link IF: 3.5
7.    Kartika Chandra Tripathy, Md Sirajullah, Deepak Kumar Mandal, and Ajay Bhandari, Delineating the effects of morphological changes on retinal hemodynamics in diabetic human retinas: An invitro investigation, Physics of Fluids Vol. 36(1), pp. 011912, January 2024 (Selected as featured by the Editor) Access Link IF: 4.6
8.    Kartika Chandra Tripathy, Ashish Siddharth and Ajay Bhandari, Image-based insilico investigation of hemodynamics and biomechanics in healthy and diabetic human retinas, Microvascular Research Vol. 150, pp. 104594, November 2023 Access Link  IF: 3.75
9.    Kartika Chandra Tripathy, Rakesh Kumar Gupta and Ajay Bhandari, Importance of nasal air conditioning in pre-septoplasty planning: A heat and mass transfer perspective, International Journal of Thermal Sciences Vol. 193, pp. 108521, November 2023 Access Link IF: 4.8
10.    Ajay Bhandari, Kartikey Jaiswal, Anup Singh and Wenbo Zhan, Highlighting the effect of heterogeneous blood perfusion on radio-frequency ablation of human brain tumors: An image-based numerical investigation, International Journal of Thermal Sciences Vol. 189, pp. 108283, Mar 2023 Access Link IF: 4.8
11.    Ajay Bhandari, Kartikey Jaiswal, Anup Singh and Wenbo Zhan, Convection-enhanced delivery of antiangiogenic drugs and liposomal cytotoxic drugs to heterogeneous brain tumour for combination therapy, Cancers Vol. 14, Issue 17, pp. 4177, August 2022 Access Link IF: 6.575
12.    Ajay Bhandari, Ocular Fluid Mechanics and Drug Delivery: A Review of Mathematical and Computational Models, Pharmaceutical Research Vol.38, Issue 12, pp. 2003-2033, December 2021 Access Link IF: 4.580
13.    Ajay Bhandari, Ankit Bansal and Niraj Sinha, Effect of Aging on Heat Transfer, Fluid Flow and Drug Transport in Anterior Human Eye: A Computational Study, Journal of Controlled Release Vol. 328, Issue 10, pp. 286-303, August, 2020, Access Link IF: 11.467
14.    Ajay Bhandari, Ankit Bansal and Niraj Sinha, Numerical Modeling of Therapeutic lens Drug Delivery in Anterior Human Eye for Treatment of Primary Open Angle Glaucoma (POAG), Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine Vol. 234, Issue 9 pp. 942-954, July, 2020, Access Link IF: 1.763
15.    Ajay Bhandari, Ankit Bansal, Anup Singh, Rakesh Kumar Gupta and Niraj Sinha, Comparison of Transport of Chemotherapeutic Drugs in Voxelized Heterogeneous Model of Human Brain Tumor, Microvascular Research. Vol. 124 pp. 76-90, March 2019, Access Link IF: 3.75
16.    Ajay Bhandari, Ankit Bansal, Rishav Jain, Anup Singh and Niraj Sinha, Effect of Tumor Volume on Drug Delivery in Heterogeneous Vasculature of Human Brain Tumors, ASME Journal of Engineering and Science in Medical Diagnostics and Therapy. Vol.2 pp. 021004 (1-10), May 2019, Access Link IF: 1.7
17.    Ajay Bhandari, Ankit Bansal, Anup Singh and Niraj Sinha, DCE-MRI Based Voxelized Computational Model for Chemotherapeutic Drug Transport in Human Brain Tumor, International Journal of Advances Engineering Science and Applied Mathematics vol. 10(4) pp. 252-262, September 2018, Access Link IF: 0.9
18.    Ajay Bhandari, Ankit Bansal, Anup Singh and Niraj Sinha, Numerical Study of Transport of Anticancer Drugs in Heterogeneous Vasculature of Human Brain Tumors Using Dynamic Contrast Enhanced- Magnetic Resonance Imaging, ASME Journal of Biomechanical Engineering. vol. 140 pp. 051010 (1-10), March 2018, Access Link IF: 1.899
19.    Ajay Bhandari, Ankit Bansal, Anup Singh and Niraj Sinha, Transport of Liposome Encapsulated drugs in Voxelized Computational Model of Human Brain Tumors, IEEE Transactions on Nano Bio Science. vol. 16(7) pp. 634-644, October 2017, Access Link IF: 3.9
20.    Ajay Bhandari, Ankit Bansal, Anup Singh and Niraj Sinha, Perfusion Kinetics in Human Brain Tumor with DCE-MRI derived model and CFD analysis, Journal of Biomechanics. Vol. 59 pp. 80-89, May 2017, Access Link IF: 2.789
 

Papers in conference abstract volumes / presented

1.    Kartika Chandra Tripathy and Ajay Bhandari, "Importance of Drug Administration Parameters on the Targeted Drug Delivery in the nasal cavities for various septal deviations" International Conference on Biological Innovation, Technology, Engineering, and Sciences -2024, 18th -20th December 2024, NIT Rourkela, India.
2.    Sourav Choudhury, Kartika Chandra Tripathy and Ajay Bhandari, "Tumor Treating Field mediated Thermosensitive Liposome Drug Delivery in Human Brain Tumors: A pilot Numerical investigation" International Conference on Biological Innovation, Technology, Engineering, and Sciences -2024, 18th -20th December 2024, NIT Rourkela, India.
3.    Gautam Kumar, Kartika Chandra Tripathy, and Ajay Bhandari, "Investigation of Hemodynamics in the Carotid Artery with Aneurysm at the Carotid-Ophthalmic Junction: An In Vitro Experiment" International Conference on Biological Innovation, Technology, Engineering, and Sciences -2024, 18th -20th December 2024, NIT Rourkela, India.
4.    Aritra Roy, Balbir Prasad, Ayan Mukherjee, and Ajay Bhandari, "Demystifying the flow dynamics of non-Newtonian fluids in electrokinetically modulated typographically patterned Channels with Physics Informed Neural Networks" International Conference on Biological Innovation, Technology, Engineering, and Sciences -2024, 18th -20th December 2024, NIT Rourkela, India.
5.    Kartika Chandra Tripathy and Ajay Bhandari, "Effect of septal correction on nasal aerodynamics – An invitro experimental and numerical investigation" International Conference on Thermo-Fluids and System Design, April 4-5, 2024, BIT Mesra, India.
6.    Sourav Choudhury, Prashant Bokam and Ajay Bhandari, "Alternative brain cancer treatment using tumor treating fields: A computational approach." International Conference on Thermo-Fluids and System Design, April 4-5, 2024, BIT Mesra, India.
7.    Dhruvjyoti Roy, Prashant Bokam and Ajay Bhandari, "Optimization of probe positioning in radiofrequency ablation of heterogeneous human brain tumor: A numerical heat transfer study" International Conference on Thermo-Fluids and System Design, April 4-5, 2024, BIT Mesra, India.
8.    Kartika Chandra Tripathy and Ajay Bhandari, “Micro-particle deposition patterns in human nasal cavity with different types of deviations” Fluid Mechanics and Fluid Power, December 20-22, 2023, IIT Jodhpur, India. 
9.    Parth Dev Bundela, Ajay Bhandari, Sarthak S. Singh; Convection enhanced drug delivery in deformable human tumors. AIP Conf. Proc. 5 September 2023; 2863 (1): 020003. Access Link.
10.    Sangly P Srinivas, Parth Dev Bundela, Yamalapalli Sowmya, Ajay Bhandari; Pharmacokinetic simulation of topical lipophilic solutes across the cornea by the finite element method. Invest. Ophthalmol. Vis. Sci. 2023;64(8):4744.Access Link.
11.    Anahita Piranfar, M. Soltani, Farshad M. Kashkooli, Wenbo Zhan, Ajay Bhandari, Arman Rahmim,” 177Lu-PSMA-617 Transport in Solid Tumor via 3D Spatio-temporal Model Reconstructed from Magnetic Resonance Image”, Society of Nuclear Medicine and Molecular Imaging, June 24-27, 2023, Chicago, Illinois, USA. Access Link.
12.    Shivam Gupta and Ajay Bhandari, “Image-based retinal hemodynamics simulation of healthy and pathological retinal vasculature” Fluid Mechanics and Fluid Power, December 14-16, 2022, IIT Roorkee, India. Access Link.
13.    Kartika Chandra Tripathy and Ajay Bhandari, “Highlighting the importance of nasal air conditioning in septoplasty using virtual correction tools: A numerical study” Fluid Mechanics and Fluid Power, December 14-16, 2022, IIT Roorkee, India. Access Link.
14.    Ajay Bhandari, Ankit Bansal and Niraj Sinha, “Comparison of efficacy of different drug delivery modes in anterior human eye for treatment of primary open angle glaucoma (POAG)”, Computational and Mathematical Biomedical Engineering, June 10-12, 2019, Tohoku University, Japan.
15.    Ashish Tiwari, Ajay Bhandari, Pankaj Wahi and Niraj Sinha, Finite Element Analysis and Computational Fluid Dynamics Study of Pore Shape in Bio-Scaffolds” International Conference on Design, Materials and Manufacturing Concerns in Production of Quality Engineering Goods, March 27-29, 2017, HBTU, Kanpur, pp. 31-37.
16.    Ajay Bhandari, Ankit Bansal, Anup Singh and Niraj Sinha, “DCE-MRI Based Voxelized Computational Model for Chemotherapeutic Drug Transport in Human Brain Tumor”, Asian Symposium on Computational Heat Transfer and Fluid Flow (ASCHT2017), 10th - 13rd December, 2017, IIT Madras, India.
17.    Ajay Bhandari, Ankit Bansal, Anup Singh and Niraj Sinha, “Study of Perfusion Kinetics in Human Brain Tumor using Leaky Tracer Kinetic Model of DCE-MRI Data and CFD”, 2017 International Conference on Life System Modeling and Simulation, Sep 22-24 2017, Nanjing, China Access Link.
18.    Ajay Bhandari, Ankit Bansal, Anup Singh and Niraj Sinha, “Transport of Liposome Encapsulated Drugs in Voxelized Computational Model of Brain Tumors”, International Conference of Nanomedicine and Nano-biotechnology, Sep 28-30, 2016, University Pierre and Marie Curie, Paris Access Link
19.    Ajay Bhandari, Ankit Bansal, Anup Singh and Niraj Sinha, “CFD Analysis of Perfusion Kinetics in Brain Tumor with DCE-MRI Derived Model”, Sixth International Congress on Computational Mechanics and Simulation, 27th June–1st July 2016, IIT Bombay, India.
 

Patents

•    Ashish Siddharth, Ajay Bhandari, and Arun Dayal Udai, Method and Equipment for Ocular Surgery and Drug Delivery (Filed). Application No: 202431060703

Projects & Activities

Sponsored Research Projects (External Funded)

1.    Project Name: Image based modelling and optimisation of convection enhanced delivery for combination therapy against heterogeneous human brain tumour

Role: Principal Investigator (PI from India) in collaboration with Dr. Wenbo Zhan (PI from UK)
Sponsoring Organization: The Royal Society (The Yusuf and Farida Hamied Foundation)
Period of Funding: 2022-2024 (2 years) Ongoing
Amount of grant: 12,000 Pounds. (Rs. 12 Lacs INR Equivalent)

2.    Project Name: Investigation of Human Retinal Vasculature for early prognosis of microaneurysm regions
Role: Principal Investigator (PI)
Sponsoring Organization: Science and Engineering Research Board (DST-SERB) under Start up research grant (SRG)
Period of Funding: 2021-2023 (2 years) Completed
Amount of grant: INR 27,61,000/- (Rs. 27.61 Lacs)

3.    Project Name: Investigation of Effect of Nasal Septum Deviation on Nasal Airflow Obstruction using Computational Fluid Dynamics and 3D Printing for Septoplasty Planning

Role: Principal Investigator (PI)
Sponsoring Organization: Indian Institute of Technology (Indian School of Mines), Dhanbad under Faculty Research Scheme (FRS)
Period of Funding: 2021-2024 (3 years) Completed
Amount of grant: INR 12,00,000/- (Rs. 12 Lacs)
 

 

Consultancy Project (for ONGC)

1.    Project Name: Technology development for the manufacturing of thin electrical steel laminations using high pressure die casting.

Role: Principal Investigator (PI from Mechanical) in collaboration with Dr. Rahul MR (PI from FMME Department)
Sponsoring Organization: Tata Steel
Period of Funding: 02/2025-07/2025 (6 months) Ongoing
Amount of grant: Rs. 12 Lacs

Membership of Scientific Societies

1. Association for Research in Vision and Ophthalmology (ARVO): Member 2025

Other Academic and Administrative Activities

GUEST EDITOR
Guest editor for special issue “Image-based Diagnostic and/or Therapeutic Agent Delivery Models in Cancer” for the Frontiers in Oncology, Frontiers in Pharmacology, and Frontiers in Radiology Journal. Access Link

RESEARCH LABS DEVELOPED

Developed Biofluids Research Lab at IIT(ISM) Dhanbad from scratch.

INVITED TALKES AND WEBINARS ORGANIZED

1.    Delivered one online lecture as an expert speaker on the topic “Emerging trends of multidisciplinary research in fluid mechanics” Short term course organized by Department of Mechanical Engineering, NIT Rourkela, INDIA in September 2023.
2.    Delivered one online lecture as an expert speaker on the topic “Basics and Application of Computational fluid Dynamics (CFD) in Understanding Human Nasal Airflow” Digital Designing and manufacturing of Pediatric Facial Prosthesis organized by Department of Oral and Maxillofacial Surgery King George’s Medical University, Lucknow in October 2021.
3.    Delivered one online lecture as an expert speaker on the topic “Image-based numerical modeling of chemotherapeutic drug transport in human brain tumors” in the AICTE sponsored Faculty Development Program on Advanced Computational Fluid Dynamics organized by the Department of Mechanical Engineering, Institute of Engineering and Technology, Lucknow in November 2020.
4.    Organized webinar as a convener on the topic “Mechanical Engineering Solutions to Biomedical Problems” sponsored by TEQIP-III in Department of Mechanical Engineering at IIT (ISM) Dhanbad from 24-27th September 2020.
 

ADMINISTRATIVE RESPONSIBILITIES

1.    Department Grievance Committee Member March 2024-till present. 
2.    Coordinator Media from April 2023-till present.
3.    Member of Department post graduate committee (DPGC) from July 2020 – July 2022.
4.    Faculty-in-Charge (FIC) Placements of Department of Mechanical Engineering from June 2022 till present. 
5.    Co-Faculty in charge of Advanced fluid mechanics and heat transfer lab.
 

Guidance

1. Kartika Chandra Tipathy (20DR0061) (Full Time) (Ongoing)

2. Gautam Kumar (23DR0246) (Full Time) (Ongoing)

3. Anjay Kumar (24DR0032) (Full Time) (Ongoing)